PHD

The Institute for Experimental Pathology based at the Center for Inflammation Research at the University of Münster, Germany offers:

In a project funded by Innovative Medizinische Forschung (IMF, Universität Münster), the research group of Dr. Mariano Malamud is investigating how pattern recognition receptors regulate immune responses during hematopoietic stress.

Neutrophils are continuously generated from hematopoietic stem and progenitor cells, and their production is rapidly reprogrammed during infection and inflammation. Although this stress response is essential for host defence, persistent or dysregulated myelopoiesis can amplify inflammatory disease. Building on our discovery that the inhibitory receptor MICL (CLEC12A) recognizes neutrophil extracellular traps and restrains neutrophil activation (Malamud et al., Nature, 2024), the project will investigate how inflammatory stress remodels pattern-recognition receptor networks during granulopoiesis and how this process programs the function of newly generated neutrophils.

The successful candidate will investigate these mechanisms using cellular, molecular, and in vivo approaches. Our institute provides a highly interdisciplinary and international environment with access to state-of-the-art flow cytometry, cell sorting, imaging, animal models, and molecular and cellular immunology platforms.

RESPONSIBILITIES

• Design and conduct experiments utilizing state-of-the-art approaches such as:
• Animal models of stress-induced granulopoiesis and bacterial infection.
• High-dimensional spectral flow cytometry and cell sorting to characterize immune cell populations in murine tissues
• Immunohistological staining and imaging of tissue sections using multiplexed immunohistochemistry
• Biochemical assays for cytokines and other inflammatory mediators
• Cell culture experiments (primary cells and cell lines)
• Collaborate closely with colleagues across disciplines to integrate findings into a comprehensive model of atherosclerosis pathophysiology
• Analyze data, interpret results, and present conclusions through high-quality publications, presentations, and reports
• Contribute to manuscript preparation
• Participate actively in departmental seminars, workshops, and conferences

REQUIREMENTS

• MSc degree in Biological Sciences
• Strong background in immunology
• Hands-on experience in one or more of the following areas:
• Flow cytometry-based phenotyping and sorting
• Immunofluorescence microscopy and histopathological evaluation
• Culture of cell lines and human or murine primary cells.
• Excellent communication skills in English; proficiency in German desirable but not required
• Ability to work independently while contributing effectively to collaborative projects
• Willingness to participate in ongoing training programs to enhance expertise and stay up-to-date with latest methodologies

WE OFFER

• Comprehensive benefits package including health insurance, pension plan, and family support services
• Access to world-class infrastructure, equipment, and resources
• Opportunities for professional growth, networking, and international collaboration
• Supportive environment fostering creativity, innovation, and interdisciplinary exchange

For inquiries, please contact: Mariano Malamud, Tel: 0251 835208, malamud@uni-muenster.de