PhD Biotechnology (m/f/d)

• Possible starting date: 01.01.2027

Our group at the University Hospital Erlangen is recruiting a highly motivated PhD candidate.

The project “P13 - Modulation of CRC development and progression by GPR15L-dependent effects on lymphocyte infiltration and the intestinal microbiota” is part of the Collaborative Research Centre TRR 417 “Cellular Communication in the Stroma of Colorectal Cancer: From Pathophysiology to Clinical Translation”, a major German research consortium (Frankfurt - Freiburg - Erlangen).

Activities and responsibilities

The PhD candidate will investigate the impact of the endogenous peptide GPR15L on the tumor microenvironment in colorectal cancer (in particular with regard to T cell recruitment and with regard to effects on the intestinal microbiome) using state-of-the art in vivo and in vitro models along with human samples.

To this end, the candidate will be trained in the following techniques:

• Multi-color flow cytometry
• Advanced mouse genetics
• State-of-the-art mouse models of colorectal cancer
• Analysis of omics data
• Organoid culture systems
• Standard molecular biology methods

Qualification profile

Your Profile:

• Completed Master's degree (or equivalent) in immunology, molecular biology, molecular medicine or related disciplines
• Strong interest in translational research
• Excellent written and spoken English
• Structured working style
• Team-oriented mindset (you will work in a working group with more than 15 colleagues and collaborate with several groups associated to the TRR417 consortium)
• Knowledge of basic molecular biology techniques such as IHC, PCR, histology, cell culture or flow cytometry
• Experience in working with mice (Felasa B) and basic knowledge of bioinformatics is advantageous
• Possible starting date: 01.01.2027

Benefits

Further information:

https://www.medizin1.uk-erlangen.de/forschung/arbeitsgruppen/ag-dr-s-zundler/

https://www.trr417.de/