Vice President Antibody Engineering (m/w/d)

pDISCO Pharmaceuticals is an emerging biotechnology company with operations in Cologne, Germany, and Schlieren, Switzerland. We leverage a proprietary mass spectrometry-based technology platform to decode the molecular architecture of the cancer cell surface. By integrating expertise in cell biology, biochemistry, and computational analytics, we identify functionally relevant protein communities and novel therapeutic targets. Our mission is to develop innovative therapies for diseases with high unmet medical need, including cancer, and to translate new biological insights into meaningful clinical applications. /ph3POSITION /h3pWe are seeking an experienced bVP Antibody Engineering /b to lead and expand our antibody and protein engineering capabilities and drive the discovery of next-generation multispecific T-cell-engager therapeutics.

This individual will play a critical role in shaping the design, optimization, and advancement of our biologics pipeline by providing scientific and strategic leadership across antibody discovery, engineering, and candidate selection. As a key member of the scientific leadership team, you will build and lead a high-performing antibody engineering organization, oversee the progression of multispecific TCE programs from concept to development candidate nomination, and collaborate closely with Discovery, Translational Sciences, CMC, and Executive Leadership to establish innovative therapeutic approaches for patients with cancer.

The role is based in Schlieren (ZH), Switzerland, and involves occasional business travel. /ph3RESPONSIBILITIES /h3ullibBuilding, leading, and continuously expanding DISCO's antibody and protein engineering capabilities /bwith a strategic focus on multispecific T-cell engager therapeutics, ensuring scientific excellence from discovery through clinical candidate nomination. /lilibProviding scientific and organizational leadership /b, building a team and fostering a collaborative, innovative, and results-oriented culture while supporting the growth and development of team members. /lilibDefining and driving lead identification and optimization strategies /b, including antibody discovery, affinity maturation, humanization, developability assessment, immunogenicity risk mitigation, and manufacturability optimization. /lilibServing as the scientific leader for antibody engineering across the

portfolio /b, providing strategic guidance on epitope selection, molecular architecture, therapeutic format selection, and structure-function relationships. /lilibLeading the design and optimization of multispecific antibodies and T-cell engagers /b, with the goal of achieving differentiated efficacy, safety, pharmacokinetic, and developability profiles. /lilibEstablishing innovative technology platforms and engineering workflows /b, including computational approaches, library design, screening strategies, and data-driven molecule optimization methods. /lilibWorking closely with cross-functional teams /b, including Discovery Biology, Translational Sciences, CMC, Clinical Development, and Project Leadership, to advance programs from target validation through candidate nomination. /lilibManaging external collaborations, technology partnerships, and CRO activities /b, ensuring high-quality

deliverables, efficient execution, and alignment with program objectives. /lilibContributing to portfolio strategy, intellectual property generation, and business development activities /b, including the evaluation of external technologies and partnership opportunities. /lilibRepresenting DISCO externally /bthrough scientific publications, conference presentations, and interactions with key opinion leaders and strategic partnersb. /b /li /ulh3YOUR PROFILE /h3h3Qualification /h3pYou hold a PhD in Biochemistry, Molecular Biology, Protein Engineering, Immunology, Chemistry, or a related life science discipline. In addition, you bring more than 14 years of relevant industry experience in biologics discovery and development, including significant leadership responsibilities within biotechnology or pharmaceutical organizations.

You have a strong track record of advancing multispecific antibody and T-cell engager programs from discovery through development candidate nomination and are passionate about translating scientific innovation into transformative therapies for patients with cancer. /ph3Experience /h3pWe expect competencies in the following areas: /pullibRecognized expertise in antibody and protein engineering /b, including design and optimization of monoclonal, bispecific, and multispecific antibodies, T-cell engagers, antibody fragments, and other complex biologics. /lilibProven track record of progressing biologics programs from discovery through candidate selection /b, ideally including multispecific T-cell engager therapeutics and immuno-oncology applications. /lilibExtensive experience in antibody discovery technologies /b, including library design, screening strategies, affinity maturation,

humanization, developability optimization, and immunogenicity assessment. /lilibDeep understanding of molecular design principles /baffecting potency, selectivity, safety, pharmacokinetics, manufacturability, and overall developability of therapeutic proteins. /lilibStrong leadership capabilities /bwith demonstrated success building, mentoring, and leading high-performing scientific teams in cross-functional and matrix organizations. /lilibExperience working across Discovery, Translational Sciences, CMC, and Development functions /bto successfully advance innovative therapeutic programs. /lilibExcellent communication and stakeholder management skills /b, including presentation of complex scientific concepts to executive leadership, external partners, and scientific audiences. /lilibA strategic, entrepreneurial, and solution-oriented mindset /b, combined with the ability to operate

effectively in a fast-paced and highly collaborative biotechnology environment. /li /ulh3WE OFFER /h3ullibLong-term /b bcareer /b bprospects /b through a permanent employment contract with a future-oriented company /lilibCompetitive /b bcompensation /b and attractive employment conditions /lilib30 /b bdays /b bof annual /b bleave /b as well as a work environment that supports professional development /lilibExciting /b bresponsibilities /b bat the interface of /b bresearch /b band /b blaboratory /b bpractice /b, offering a high degree of autonomy and opportunities to make an impact /lilibA /b bcollaborative, international /b bcorporate /b bculture /b with flat hierarchies, short decision-making processes, and regular team activities /li /ul